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Synthesis and controlled release properties of prednisone intercalated Mg−Al layered double hydroxide composite / Fusu Li in Industrial & engineering chemistry research, Vol. 48 N° 12 (Juin 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 12 (Juin 2009) . - pp. 5590–5597 Titre : Synthesis and controlled release properties of prednisone intercalated Mg−Al layered double hydroxide composite Type de document : texte imprimé Auteurs : Fusu Li, Auteur ; Lan Jin, Auteur ; Jingbin Han, Auteur Année de publication : 2009 Article en page(s) : pp. 5590–5597 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Drug-inorganic  composite  Prednisone-cholate  ion  micelles  Mg-Al  layered  double  hydroxide  X-ray  diffraction  Fourier  transform  infrared  UV-vis  absorption  spectroscopy Résumé : A drug−inorganic composite involving prednisone−cholate ion micelles intercalated Mg−Al layered double hydroxide (LDH) has been assembled by a coprecipitation method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV−vis absorption spectroscopy indicate a successful intercalation of prednisone-containing micelles into galleries of the LDH matrix. The in vitro drug release studies show that no burst release phenomenon was observed at the beginning of release tests, and the pH value imposes very little influence on the release performance of prednisone in the studied pH range 4.8−7.6. It is, therefore, concluded that the MgAl-LDH can be used as an excellent inorganic drug carrier for prednisone in a wide range of pH values. Four kinetic models (first-order equation, Higuchi equation, Bhaskas equation, and Ritger−Peppas equation) were chosen to study the release kinetics of prednisone from the LDH carrier, and it was found that this process can be described by the Ritger−Peppas equation satisfactorily based on a directing Excel-based solver (DEBS). Moreover, the mechanism for drug release was also discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900043r [article] Synthesis and controlled release properties of prednisone intercalated Mg−Al layered double hydroxide composite [texte imprimé] / Fusu Li, Auteur ; Lan Jin, Auteur ; Jingbin Han, Auteur . - 2009 . - pp. 5590–5597. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 12 (Juin 2009) . - pp. 5590–5597 Mots-clés : Drug-inorganic  composite  Prednisone-cholate  ion  micelles  Mg-Al  layered  double  hydroxide  X-ray  diffraction  Fourier  transform  infrared  UV-vis  absorption  spectroscopy Résumé : A drug−inorganic composite involving prednisone−cholate ion micelles intercalated Mg−Al layered double hydroxide (LDH) has been assembled by a coprecipitation method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV−vis absorption spectroscopy indicate a successful intercalation of prednisone-containing micelles into galleries of the LDH matrix. The in vitro drug release studies show that no burst release phenomenon was observed at the beginning of release tests, and the pH value imposes very little influence on the release performance of prednisone in the studied pH range 4.8−7.6. It is, therefore, concluded that the MgAl-LDH can be used as an excellent inorganic drug carrier for prednisone in a wide range of pH values. Four kinetic models (first-order equation, Higuchi equation, Bhaskas equation, and Ritger−Peppas equation) were chosen to study the release kinetics of prednisone from the LDH carrier, and it was found that this process can be described by the Ritger−Peppas equation satisfactorily based on a directing Excel-based solver (DEBS). Moreover, the mechanism for drug release was also discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900043r