Powder micronization using a CO2 supercritical antisolvent type process / Olivier Boutin in Industrial & engineering chemistry research, Vol. 48 N° 12 (Juin 2009)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 48 N° 12 (Juin 2009) . - pp. 5671–5678 Titre : Powder micronization using a CO2 supercritical antisolvent type process : comparison of different introduction devices Type de document : texte imprimé Auteurs : Olivier Boutin, Auteur ; Thomas Petit-Gas, Auteur ; Elisabeth Badens, Auteur Année de publication : 2009 Article en page(s) : pp. 5671–5678 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : CO2 antisolvent Recrystallization processes Impinging jets Concentric tube reactor Résumé : Many recrystallization processes in supercritical medium utilize CO2 as antisolvent. This work presents two introduction devices based on the principle of the supercritical antisolvent process: the impinging jets and the concentric tube antisolvent reactor. Those two processes are very simple to develop and allow improving the mixing between the two phases. Some experiments have been conducted for the impinging jets using L-polylactic acid at 10 MPa and 308 K giving spherical particles with average diameter varying from 1.4 to 2.3 μm. For the concentric tube antisolvent reactor, griseofulvin was tested at 10 MPa and temperatures between 308 and 323 K providing needles with lengths between 25 and 50 μm. These results combined with previous ones allow comparing these introduction devices with the classical supercritical antisolvent (SAS) process, demonstrating the following improvements: (i) reduction of particle size, (ii) increase in initial solute concentration, and (iii) process intensification. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8017803 [article] Powder micronization using a CO2 supercritical antisolvent type process : comparison of different introduction devices [texte imprimé] / Olivier Boutin, Auteur ; Thomas Petit-Gas, Auteur ; Elisabeth Badens, Auteur . - 2009 . - pp. 5671–5678. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 12 (Juin 2009) . - pp. 5671–5678 Mots-clés : CO2 antisolvent Recrystallization processes Impinging jets Concentric tube reactor Résumé : Many recrystallization processes in supercritical medium utilize CO2 as antisolvent. This work presents two introduction devices based on the principle of the supercritical antisolvent process: the impinging jets and the concentric tube antisolvent reactor. Those two processes are very simple to develop and allow improving the mixing between the two phases. Some experiments have been conducted for the impinging jets using L-polylactic acid at 10 MPa and 308 K giving spherical particles with average diameter varying from 1.4 to 2.3 μm. For the concentric tube antisolvent reactor, griseofulvin was tested at 10 MPa and temperatures between 308 and 323 K providing needles with lengths between 25 and 50 μm. These results combined with previous ones allow comparing these introduction devices with the classical supercritical antisolvent (SAS) process, demonstrating the following improvements: (i) reduction of particle size, (ii) increase in initial solute concentration, and (iii) process intensification. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8017803

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