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Nanostructured PLLA-hydroxyapatite scaffolds produced by a supercritical assisted technique / Ernesto Reverchon in Industrial & engineering chemistry research, Vol. 48 N° 11 (Juin 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 11 (Juin 2009) . - pp. 5310–5316 Titre : Nanostructured PLLA-hydroxyapatite scaffolds produced by a supercritical assisted technique Type de document : texte imprimé Auteurs : Ernesto Reverchon, Auteur ; Paola Pisanti, Auteur ; Stefano Cardea, Auteur Année de publication : 2009 Article en page(s) : pp. 5310–5316 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Bone  scaffolds  Nanostructural  properties  Supercritical  fluid  assisted  technique  Hydroxyapatite  nanoparticles Résumé : Temporary bone scaffolds can surrogate the extracellular matrix to favor the regeneration of tissues and organs. It is very difficult to obtain the coexistence of the macro-, micro-, and nanostructural properties necessary to mimic the organization of the human bone. To obtain all of these characteristics, we tested a supercritical fluid assisted technique for the formation of PLLA/ceramic scaffolds using hydroxyapatite (HA) nanoparticles loaded at up to 50% by weight of the polymer to improve the biomimethism and the mechanical properties of the scaffolds. We produced poly(l-lactic acid) scaffolds in relatively short time (<30 h), with a porosity higher than 90% and with a high interconnectivity. An internal structure formed by very long nanofibers of 200−400 nm diameter and prefixed macroscopic shape and size was also obtained. A maximum compressive modulus of 123 kPa was obtained, and the solvent residue was lower than 5 ppm. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8018752 [article] Nanostructured PLLA-hydroxyapatite scaffolds produced by a supercritical assisted technique [texte imprimé] / Ernesto Reverchon, Auteur ; Paola Pisanti, Auteur ; Stefano Cardea, Auteur . - 2009 . - pp. 5310–5316. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 11 (Juin 2009) . - pp. 5310–5316 Mots-clés : Bone  scaffolds  Nanostructural  properties  Supercritical  fluid  assisted  technique  Hydroxyapatite  nanoparticles Résumé : Temporary bone scaffolds can surrogate the extracellular matrix to favor the regeneration of tissues and organs. It is very difficult to obtain the coexistence of the macro-, micro-, and nanostructural properties necessary to mimic the organization of the human bone. To obtain all of these characteristics, we tested a supercritical fluid assisted technique for the formation of PLLA/ceramic scaffolds using hydroxyapatite (HA) nanoparticles loaded at up to 50% by weight of the polymer to improve the biomimethism and the mechanical properties of the scaffolds. We produced poly(l-lactic acid) scaffolds in relatively short time (<30 h), with a porosity higher than 90% and with a high interconnectivity. An internal structure formed by very long nanofibers of 200−400 nm diameter and prefixed macroscopic shape and size was also obtained. A maximum compressive modulus of 123 kPa was obtained, and the solvent residue was lower than 5 ppm. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8018752