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Assessment of the integral resource consumption of individual chemical production processes in a multipurpose pharmaceutical production plant / Geert Van der Vorst in Industrial & engineering chemistry research, Vol. 48 N° 11 (Juin 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 11 (Juin 2009) . - pp. 5344–5350 Titre : Assessment of the integral resource consumption of individual chemical production processes in a multipurpose pharmaceutical production plant : a complex task Type de document : texte imprimé Auteurs : Geert Van der Vorst, Auteur ; Jo Dewulf, Auteur ; Wim Aelterman, Auteur Année de publication : 2009 Article en page(s) : pp. 5344–5350 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Integral  resource  consumption  Multipurpose  plants  Integral  mass  Energy  balances Résumé : Up to now, process specific integral resource consumption is barely used as criterion for the selection and improvement of fine chemical and pharmaceutical production processes. Reasons are the complexity of the supply networks in multipurpose plants and the requirement of a detailed data inventory from the production plant itself and from facilities delivering supporting utilities and treating waste streams. In this paper, a methodology is presented to set up integral mass and energy balances of specific production processes in the pharmaceutical and fine chemical industry. This methodology is based on the principle that each chemical production process is a sequence of unit operations in which basic operations at individual equipment take place. These basic operations are considered as the building blocks for all production processes. If the resource consumption of each building block can be quantified, not only at the operation itself but also at the on-site and off-site upstream and downstream processes to sustain the operation, the integral resource requirement of a whole specific production process can be quantified by the summation of the resource requirements of all building blocks involved. This methodology allows the development of a calculation tool for the quantification of the integral resource consumption with minimized data inventory. This tool will enable the selection of the most resource efficient production process and will indicate points of improvement. In this way production processes in pharmaceutical and fine chemical industries can become economically and ecologically more sustainable. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8015335 [article] Assessment of the integral resource consumption of individual chemical production processes in a multipurpose pharmaceutical production plant : a complex task [texte imprimé] / Geert Van der Vorst, Auteur ; Jo Dewulf, Auteur ; Wim Aelterman, Auteur . - 2009 . - pp. 5344–5350. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 11 (Juin 2009) . - pp. 5344–5350 Mots-clés : Integral  resource  consumption  Multipurpose  plants  Integral  mass  Energy  balances Résumé : Up to now, process specific integral resource consumption is barely used as criterion for the selection and improvement of fine chemical and pharmaceutical production processes. Reasons are the complexity of the supply networks in multipurpose plants and the requirement of a detailed data inventory from the production plant itself and from facilities delivering supporting utilities and treating waste streams. In this paper, a methodology is presented to set up integral mass and energy balances of specific production processes in the pharmaceutical and fine chemical industry. This methodology is based on the principle that each chemical production process is a sequence of unit operations in which basic operations at individual equipment take place. These basic operations are considered as the building blocks for all production processes. If the resource consumption of each building block can be quantified, not only at the operation itself but also at the on-site and off-site upstream and downstream processes to sustain the operation, the integral resource requirement of a whole specific production process can be quantified by the summation of the resource requirements of all building blocks involved. This methodology allows the development of a calculation tool for the quantification of the integral resource consumption with minimized data inventory. This tool will enable the selection of the most resource efficient production process and will indicate points of improvement. In this way production processes in pharmaceutical and fine chemical industries can become economically and ecologically more sustainable. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8015335