Documents disponibles écrits par cet auteur

Production of norfloxacin nanosuspensions using microfluidics reaction technology through solvent/antisolvent crystallization / Thomai Panagiotou in Industrial & engineering chemistry research, Vol. 48 N°4 (Février 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N°4 (Février 2009) . - pp. 1761–1771 Titre : Production of norfloxacin nanosuspensions using microfluidics reaction technology through solvent/antisolvent crystallization Type de document : texte imprimé Auteurs : Thomai Panagiotou, Auteur ; Steven V. Mesite, Auteur ; Robert J. Fisher, Auteur Année de publication : 2009 Article en page(s) : pp. 1761–1771 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Norfloxacin  nanosuspensions  Microfluidics  reaction  technology  Crystalline  structure Résumé : Hydrophobic active pharmaceutical ingredients (APIs) are often difficult to deliver effectively because of formulation limitations. Nanosuspensions of such drugs may be used to increase bioavailability and offer a variety of delivery options including injection, inhalation, oral, and transdermal. Microfluidics reaction technology (MRT) was used successfully to produce submicrometer API suspensions via a continuous process that involves solvent/antisolvent crystallization. As proof of concept, nanosuspensions of norfloxacin (NFN), an antibacterial agent, were produced varying the key parameters of the technology. The nanosuspensions had narrow particle size distributions and median particle sizes in the range of 170−350 nm. The particle size depends on the supersaturation ratio and energy dissipation expressed as processing pressure. However, the particle size was found to be insensitive to the presence of the surfactant used. The crystalline structure of NFN was not affected by the mixing intensity but by the solvent/antisolvent system. This “bottom up” process for creating nanosuspensions was compared to a “top down” process, in which NFN nanosuspensions were created as a result of particle size reduction. It was found that the “bottom up” process was substantially more efficient and resulted in smaller particles than the “top down” process. MRT is based on an impinging jet reactor design with jet velocities and energy dissipation that is orders of magnitude higher than those of conventional impinging jet reactors. The technology provides precise control of the feed rates and the subsequent location and intensity of mixing of the reactants. It may be the best choice economically due to its process intensification character that minimizes energy requirements and the proven scalability of the reactor. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800955t [article] Production of norfloxacin nanosuspensions using microfluidics reaction technology through solvent/antisolvent crystallization [texte imprimé] / Thomai Panagiotou, Auteur ; Steven V. Mesite, Auteur ; Robert J. Fisher, Auteur . - 2009 . - pp. 1761–1771. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N°4 (Février 2009) . - pp. 1761–1771 Mots-clés : Norfloxacin  nanosuspensions  Microfluidics  reaction  technology  Crystalline  structure Résumé : Hydrophobic active pharmaceutical ingredients (APIs) are often difficult to deliver effectively because of formulation limitations. Nanosuspensions of such drugs may be used to increase bioavailability and offer a variety of delivery options including injection, inhalation, oral, and transdermal. Microfluidics reaction technology (MRT) was used successfully to produce submicrometer API suspensions via a continuous process that involves solvent/antisolvent crystallization. As proof of concept, nanosuspensions of norfloxacin (NFN), an antibacterial agent, were produced varying the key parameters of the technology. The nanosuspensions had narrow particle size distributions and median particle sizes in the range of 170−350 nm. The particle size depends on the supersaturation ratio and energy dissipation expressed as processing pressure. However, the particle size was found to be insensitive to the presence of the surfactant used. The crystalline structure of NFN was not affected by the mixing intensity but by the solvent/antisolvent system. This “bottom up” process for creating nanosuspensions was compared to a “top down” process, in which NFN nanosuspensions were created as a result of particle size reduction. It was found that the “bottom up” process was substantially more efficient and resulted in smaller particles than the “top down” process. MRT is based on an impinging jet reactor design with jet velocities and energy dissipation that is orders of magnitude higher than those of conventional impinging jet reactors. The technology provides precise control of the feed rates and the subsequent location and intensity of mixing of the reactants. It may be the best choice economically due to its process intensification character that minimizes energy requirements and the proven scalability of the reactor. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800955t