Block copolymer micelles formed in supercritical fluid can become water-dispensable nanoparticles / Zachary Tyrrell in Industrial & engineering chemistry research, Vol. 48 N°4 (Février 2009)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 48 N°4 (Février 2009) . - pp. 1928–1932 Titre : Block copolymer micelles formed in supercritical fluid can become water-dispensable nanoparticles : poly(ethylene glycol)-block-poly(ϵ-caprolactone) in trifluoromethane Type de document : texte imprimé Auteurs : Zachary Tyrrell, Auteur ; Winoto Winoto, Auteur ; Youqing Shen, Auteur Année de publication : 2009 Article en page(s) : pp. 1928–1932 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Micelles Poly(ethylene glycol)−  block Poly(ϵ  -caprolactone)Supercritical fluid solvent Water-dispensable formulation Résumé : Micelles of hydrophilic−hydrophobic block polymers, such as poly(ethylene glycol)−block-poly(ϵ-caprolactone) (PEG−b-PCL), used as drug-delivery carriers, are generally fabricated via solvent displacement or dialysis, which is time-consuming, requires freeze drying, and can leave toxic traces of the residual organic solvents. An alternative is presented in this paper: form micellar PEG−b-PCL nanoparticles in a supercritical fluid solvent and then disperse them in water toward a water-dispensable formulation. This method is illustrated with pressure−temperature phase diagrams for PEG−b-PCL in supercritical trifluoromethane, which is selective enough for the PCL and PEG blocks to induce micellization. When subjected to decompression to remove trifluoromethane, dry and organic solvent-free nanoparticles are readily obtained. Their micellar structure is immediately reestablished in water, as confirmed by laser light scattering. Neither has been demonstrated previously. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801472n [article] Block copolymer micelles formed in supercritical fluid can become water-dispensable nanoparticles : poly(ethylene glycol)-block-poly(ϵ-caprolactone) in trifluoromethane [texte imprimé] / Zachary Tyrrell, Auteur ; Winoto Winoto, Auteur ; Youqing Shen, Auteur . - 2009 . - pp. 1928–1932. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N°4 (Février 2009) . - pp. 1928–1932 Mots-clés : Micelles Poly(ethylene glycol)−  block Poly(ϵ  -caprolactone)Supercritical fluid solvent Water-dispensable formulation Résumé : Micelles of hydrophilic−hydrophobic block polymers, such as poly(ethylene glycol)−block-poly(ϵ-caprolactone) (PEG−b-PCL), used as drug-delivery carriers, are generally fabricated via solvent displacement or dialysis, which is time-consuming, requires freeze drying, and can leave toxic traces of the residual organic solvents. An alternative is presented in this paper: form micellar PEG−b-PCL nanoparticles in a supercritical fluid solvent and then disperse them in water toward a water-dispensable formulation. This method is illustrated with pressure−temperature phase diagrams for PEG−b-PCL in supercritical trifluoromethane, which is selective enough for the PCL and PEG blocks to induce micellization. When subjected to decompression to remove trifluoromethane, dry and organic solvent-free nanoparticles are readily obtained. Their micellar structure is immediately reestablished in water, as confirmed by laser light scattering. Neither has been demonstrated previously. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801472n

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