Reaction of finasteride intermediate with benzeneseleninic anhydride / Ch. Suchitra in Industrial & engineering chemistry research, Vol. 47 N° 23 (Décembre 2008)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9201–9205 Titre : Reaction of finasteride intermediate with benzeneseleninic anhydride : an in-Depth study Type de document : texte imprimé Auteurs : Ch. Suchitra, Auteur ; Kalyani Maitra, Auteur ; Dilip Raut, Auteur Année de publication : 2009 Article en page(s) : p. 9201–9205 Note générale : Chemistry engineering Langues : Anglais (eng) Mots-clés : Finasteride Intermediate Benzeneseleninic Anhydride In-Depth Study Résumé : One of the intermediates of finasteride was oxidized by the reaction of benzeneseleninic (BS) anhydride in refluxing toluene for 16 h. Sometimes, the desired product was obtained, and sometimes, there was no yield or very low yield at the end of the reaction time. To obtain a better understanding of such variations, laboratory syntheses were conducted with commercial BS anhydride, pure BS anhydride, pure BS acid, and mixtures of anhydride and acid samples. During the reaction, the intermediate reaction masses were analyzed by high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) at predetermined times and correlated with differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) samples. The DSC and XRPD data indicated that commercial BS anhydride samples did not always consist of the pure anhydride form. When the BS acid was present in the anhydride sample, the reaction rate was lower than that of the pure BS anhydride sample. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800530c [article] Reaction of finasteride intermediate with benzeneseleninic anhydride : an in-Depth study [texte imprimé] / Ch. Suchitra, Auteur ; Kalyani Maitra, Auteur ; Dilip Raut, Auteur . - 2009 . - p. 9201–9205. Chemistry engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N° 23 (Décembre 2008) . - p. 9201–9205 Mots-clés : Finasteride Intermediate Benzeneseleninic Anhydride In-Depth Study Résumé : One of the intermediates of finasteride was oxidized by the reaction of benzeneseleninic (BS) anhydride in refluxing toluene for 16 h. Sometimes, the desired product was obtained, and sometimes, there was no yield or very low yield at the end of the reaction time. To obtain a better understanding of such variations, laboratory syntheses were conducted with commercial BS anhydride, pure BS anhydride, pure BS acid, and mixtures of anhydride and acid samples. During the reaction, the intermediate reaction masses were analyzed by high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) at predetermined times and correlated with differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) samples. The DSC and XRPD data indicated that commercial BS anhydride samples did not always consist of the pure anhydride form. When the BS acid was present in the anhydride sample, the reaction rate was lower than that of the pure BS anhydride sample. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800530c

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