Hydrogenation of amino acid mixtures to amino alcohols / Ketan P. Pimparkar in Industrial & engineering chemistry research, Vol. 47 N°20 (Octobre 2008)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 47 N°20 (Octobre 2008) . - P. 7648-7653 Titre : Hydrogenation of amino acid mixtures to amino alcohols Type de document : texte imprimé Auteurs : Ketan P. Pimparkar, Éditeur scientifique ; Dennis J. Miller, Éditeur scientifique ; James E. Jackson, Éditeur scientifique Année de publication : 2008 Article en page(s) : P. 7648-7653 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Amino acid alcohols Résumé : Amino alcohols are important building blocks for a variety of pharmaceutical, insecticidal, and other specialty compounds. Hydrogenation of amino acids to amino alcohols is a route that allows for the incorporation of biorenewable-derived chemicals into traditional petroleum-based industrial processes. This study examines the effect of multiple substrates on aqueous-phase hydrogenation rates of the amino acids serine, alanine, and valine. Hydrogenation reactions were carried out in a high-pressure reactor at 7.0 MPa hydrogen pressure and 130 °C over carbon supported ruthenium catalyst. Samples taken at regular intervals and analyzed by high-performance liquid chromatography allowed calculation of conversion rates and product yields. In general, competition between the amino acid substrates results in reduced reaction rates relative to that for hydrogenation of a single amino acid substrate. Kinetics of mixed amino acid hydrogenation was modeled using a Langmuir−Hinshelwood-type mechanism with surface reaction as the rate-limiting step. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800351x [article] Hydrogenation of amino acid mixtures to amino alcohols [texte imprimé] / Ketan P. Pimparkar, Éditeur scientifique ; Dennis J. Miller, Éditeur scientifique ; James E. Jackson, Éditeur scientifique . - 2008 . - P. 7648-7653. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N°20 (Octobre 2008) . - P. 7648-7653 Mots-clés : Amino acid alcohols Résumé : Amino alcohols are important building blocks for a variety of pharmaceutical, insecticidal, and other specialty compounds. Hydrogenation of amino acids to amino alcohols is a route that allows for the incorporation of biorenewable-derived chemicals into traditional petroleum-based industrial processes. This study examines the effect of multiple substrates on aqueous-phase hydrogenation rates of the amino acids serine, alanine, and valine. Hydrogenation reactions were carried out in a high-pressure reactor at 7.0 MPa hydrogen pressure and 130 °C over carbon supported ruthenium catalyst. Samples taken at regular intervals and analyzed by high-performance liquid chromatography allowed calculation of conversion rates and product yields. In general, competition between the amino acid substrates results in reduced reaction rates relative to that for hydrogenation of a single amino acid substrate. Kinetics of mixed amino acid hydrogenation was modeled using a Langmuir−Hinshelwood-type mechanism with surface reaction as the rate-limiting step. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800351x

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