How Is effective enantioselectivity of immobilized enzyme in kinetic resolution of racemate affected in a fixed-bed reactor? / Hongwei Yu ; Chi Bun Ching in Industrial & engineering chemistry research, Vol. 47 n°22 (Novembre 2008)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 47 n°22 (Novembre 2008) . - p. 8808–8814 Titre : How Is effective enantioselectivity of immobilized enzyme in kinetic resolution of racemate affected in a fixed-bed reactor? Type de document : texte imprimé Auteurs : Hongwei Yu, Auteur ; Chi Bun Ching, Auteur Année de publication : 2008 Article en page(s) : p. 8808–8814 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Enantioselectivity Résumé : The purpose of this theoretical discussion is to help researchers understand how some parameters and reaction type (first-order and Michaelis−Menten kinetic) could impact effective enantioselectivity of enzyme in a fixed-bed reactor, including adsorption equilibrium constant (adsorption effect), Biot number, Peclet number, and bed length parameter. The theoretical analysis clearly derives that reaction rate is able to impact the effective enantioselectivity of enzyme through controlling the loading of enzyme on the solid support. In addition, adsorption phenomenon and reaction type have no effect on the effective enantioselectivity in a fixed-bed reactor. Among these parameters, Bi ( En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800429e [article] How Is effective enantioselectivity of immobilized enzyme in kinetic resolution of racemate affected in a fixed-bed reactor? [texte imprimé] / Hongwei Yu, Auteur ; Chi Bun Ching, Auteur . - 2008 . - p. 8808–8814. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 n°22 (Novembre 2008) . - p. 8808–8814 Mots-clés : Enantioselectivity Résumé : The purpose of this theoretical discussion is to help researchers understand how some parameters and reaction type (first-order and Michaelis−Menten kinetic) could impact effective enantioselectivity of enzyme in a fixed-bed reactor, including adsorption equilibrium constant (adsorption effect), Biot number, Peclet number, and bed length parameter. The theoretical analysis clearly derives that reaction rate is able to impact the effective enantioselectivity of enzyme through controlling the loading of enzyme on the solid support. In addition, adsorption phenomenon and reaction type have no effect on the effective enantioselectivity in a fixed-bed reactor. Among these parameters, Bi ( En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800429e

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Theoretical analysis of the adsorption effect on kinetic resolution of racemates catalyzed by immobilized enzymes in a batch reactor / Hongwei Yu in Industrial & engineering chemistry research, Vol. 47 n°12 (Juin 2008)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 47 n°12 (Juin 2008) . - p. 4251–4255 Titre : Theoretical analysis of the adsorption effect on kinetic resolution of racemates catalyzed by immobilized enzymes in a batch reactor Type de document : texte imprimé Auteurs : Hongwei Yu, Auteur ; Chi Bun Ching, Auteur Année de publication : 2008 Article en page(s) : p. 4251–4255 Note générale : Bibliogr. p. 4255 Langues : Anglais (eng) Mots-clés : Adsorption  Kinetic resolution  Racemate catalyzed Résumé : Adsorption, a typical physical phenomenon, always neglected in the kinetic resolution of the racemate catalyzed by enzymes immobilized on the porous solid support, was theoretically analyzed. A concept that the adsorption effect plays an important role to affect the superficial performance of the enzyme which is often applied to evaluate the performance of the enzyme was described. Adsorption intensity, or so-called mass equilibrium constant (K), is the most important factor to affect the performance of the enzyme compared with adsorption rate coefficient (k) and adsorption equilibrium (adsorption isotherm) if the solid support with chiral selectivity is applied. The conclusion can be drawn that the solid support with a weak adsorption effect on the racemate may favorite the enzyme to exhibit a good performance in the kinetic resolution of the racemate. The adsorption phenomenon should be considered as an explanation to the performance changing of the enzyme after immobilized. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie071300t [article] Theoretical analysis of the adsorption effect on kinetic resolution of racemates catalyzed by immobilized enzymes in a batch reactor [texte imprimé] / Hongwei Yu, Auteur ; Chi Bun Ching, Auteur . - 2008 . - p. 4251–4255. Bibliogr. p. 4255 Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 n°12 (Juin 2008) . - p. 4251–4255 Mots-clés : Adsorption  Kinetic resolution  Racemate catalyzed Résumé : Adsorption, a typical physical phenomenon, always neglected in the kinetic resolution of the racemate catalyzed by enzymes immobilized on the porous solid support, was theoretically analyzed. A concept that the adsorption effect plays an important role to affect the superficial performance of the enzyme which is often applied to evaluate the performance of the enzyme was described. Adsorption intensity, or so-called mass equilibrium constant (K), is the most important factor to affect the performance of the enzyme compared with adsorption rate coefficient (k) and adsorption equilibrium (adsorption isotherm) if the solid support with chiral selectivity is applied. The conclusion can be drawn that the solid support with a weak adsorption effect on the racemate may favorite the enzyme to exhibit a good performance in the kinetic resolution of the racemate. The adsorption phenomenon should be considered as an explanation to the performance changing of the enzyme after immobilized. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie071300t

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