Use of “bricks and mortar” model to predict transdermal permeation / Longjian Chen in Industrial & engineering chemistry research, Vol. 47 N°17 (Septembre 2008)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 47 N°17 (Septembre 2008) . - p. 6465–6472 Titre : Use of “bricks and mortar” model to predict transdermal permeation : model development and initial validation Type de document : texte imprimé Auteurs : Longjian Chen, Auteur ; Guoping Lian, Auteur ; Lujia Han, Auteur Année de publication : 2008 Article en page(s) : p. 6465–6472 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Transdermal permeation Bricks and mortar model Résumé : Presented in this paper is a general purpose computer model for predicting transdermal permeation of solutes in vivo. The “bricks and mortar” model is employed to represent the stratum corneum (SC), the main barrier to transdermal permeation. Transdermal permeation and absorption is modeled as a dynamic process of mass transfer in the heterogeneous stratum corneum including both the tortuous lipid pathway and the transcellular corneocytes pathway. The partition and diffusion properties of solutes in SC lipid matrix and corneocytes are calculated from the fundamental physical chemical properties of octanol−water partition coefficient, molecular size, and diffusion coefficients in water and lipid, using equations established elsewhere. To test the model, the in vivo tape striping data of 4-cyanophenol is simulated. Using the calculated partition and diffusion properties of 4-cyanophenol in SC lipids and corneocytes, the predicted dynamic profiles of 4-cyanophenol in the SC agreed very well with the experimental data. Results show that for a moderately hydrophobic solute like 4-cyanophenol, the transcellular pathway is also an important route of percutaneous absorption with about 2/3 of the absorbed 4-cyanophenol partitioned into the corneocytes. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie701711v [article] Use of “bricks and mortar” model to predict transdermal permeation : model development and initial validation [texte imprimé] / Longjian Chen, Auteur ; Guoping Lian, Auteur ; Lujia Han, Auteur . - 2008 . - p. 6465–6472. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N°17 (Septembre 2008) . - p. 6465–6472 Mots-clés : Transdermal permeation Bricks and mortar model Résumé : Presented in this paper is a general purpose computer model for predicting transdermal permeation of solutes in vivo. The “bricks and mortar” model is employed to represent the stratum corneum (SC), the main barrier to transdermal permeation. Transdermal permeation and absorption is modeled as a dynamic process of mass transfer in the heterogeneous stratum corneum including both the tortuous lipid pathway and the transcellular corneocytes pathway. The partition and diffusion properties of solutes in SC lipid matrix and corneocytes are calculated from the fundamental physical chemical properties of octanol−water partition coefficient, molecular size, and diffusion coefficients in water and lipid, using equations established elsewhere. To test the model, the in vivo tape striping data of 4-cyanophenol is simulated. Using the calculated partition and diffusion properties of 4-cyanophenol in SC lipids and corneocytes, the predicted dynamic profiles of 4-cyanophenol in the SC agreed very well with the experimental data. Results show that for a moderately hydrophobic solute like 4-cyanophenol, the transcellular pathway is also an important route of percutaneous absorption with about 2/3 of the absorbed 4-cyanophenol partitioned into the corneocytes. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie701711v

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