Unit operations characterization using historical manufacturing performance / Jerry D. Mitchell in Industrial & engineering chemistry research, Vol. 47 N°17 (Septembre 2008)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 47 N°17 (Septembre 2008) . - p. 6612–6621 Titre : Unit operations characterization using historical manufacturing performance Type de document : texte imprimé Auteurs : Jerry D. Mitchell, Auteur ; Kumar Abhinava, Auteur ; Kristi L. Griffiths, Auteur Année de publication : 2008 Article en page(s) : p. 6612–6621 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Unit operations Manufacturing performance Flexibility Résumé : Collecting unit operation performance data on manufacturing processes has many benefits. Besides assessing the health of assets, the data can also be analyzed to drive process improvement activities, to assist in establishing practical operating ranges for new products, and can be used to facilitate process development activities in the laboratory ultimately leading to more robust tech transfers of processes to the manufacturing facility. In this paper, we will describe how to obtain operational variability on the basis of performance data extracted from current and/or historical manufacturing unit operations and its practical uses. Although, the concept was developed initially as a small molecule process design tool, its flexibility is underscored by including an example of how a parenteral manufacturing site used it to identify and correct an issue before it translated into unplanned downtime or product loss. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie071256h [article] Unit operations characterization using historical manufacturing performance [texte imprimé] / Jerry D. Mitchell, Auteur ; Kumar Abhinava, Auteur ; Kristi L. Griffiths, Auteur . - 2008 . - p. 6612–6621. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N°17 (Septembre 2008) . - p. 6612–6621 Mots-clés : Unit operations Manufacturing performance Flexibility Résumé : Collecting unit operation performance data on manufacturing processes has many benefits. Besides assessing the health of assets, the data can also be analyzed to drive process improvement activities, to assist in establishing practical operating ranges for new products, and can be used to facilitate process development activities in the laboratory ultimately leading to more robust tech transfers of processes to the manufacturing facility. In this paper, we will describe how to obtain operational variability on the basis of performance data extracted from current and/or historical manufacturing unit operations and its practical uses. Although, the concept was developed initially as a small molecule process design tool, its flexibility is underscored by including an example of how a parenteral manufacturing site used it to identify and correct an issue before it translated into unplanned downtime or product loss. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie071256h

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