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Separation and purification of schisandrin B from fructus schisandrae / Ka F. Luk in Industrial & engineering chemistry research, Vol. 47 n°12 (Juin 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 n°12 (Juin 2008) . - p. 4193–4201 Titre : Separation and purification of schisandrin B from fructus schisandrae Type de document : texte imprimé Auteurs : Ka F. Luk, Auteur ; Kam M. Ko, Auteur ; Ka M. Ng, Auteur Année de publication : 2008 Article en page(s) : p. 4193–4201 Note générale : Bibliogr. p. 4201 Langues : Anglais (eng) Mots-clés : Schisandrin  B;  Fructus  Schisandrae;  Solid–liquid  extraction;  Adsorption-desorption Résumé : Schisandrin B (Sch B) is the most abundant and biologically active dibenzocyclooctadiene lignan present in Fructus Schisandrae (FS). It is a highly desirable ingredient for a dietary supplement. While Sch B has been isolated from FS in the laboratory, the experimental procedure was usually lengthy and the yield was relatively low. The objective of this study is to develop a process that is amenable to large-scale recovery of Sch B from FS. The process starts with solid–liquid extraction of FS by petroleum ether to yield a Sch B-containing extract, which is then purified by removing the relatively nonpolar substances, mostly fatty oils, by an adsorption–desorption step. This is followed by a chromatographic process to isolate the Sch B-enriched fraction that is then used to yield Sch B by crystallization. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie071317b [article] Separation and purification of schisandrin B from fructus schisandrae [texte imprimé] / Ka F. Luk, Auteur ; Kam M. Ko, Auteur ; Ka M. Ng, Auteur . - 2008 . - p. 4193–4201. Bibliogr. p. 4201 Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 n°12 (Juin 2008) . - p. 4193–4201 Mots-clés : Schisandrin  B;  Fructus  Schisandrae;  Solid–liquid  extraction;  Adsorption-desorption Résumé : Schisandrin B (Sch B) is the most abundant and biologically active dibenzocyclooctadiene lignan present in Fructus Schisandrae (FS). It is a highly desirable ingredient for a dietary supplement. While Sch B has been isolated from FS in the laboratory, the experimental procedure was usually lengthy and the yield was relatively low. The objective of this study is to develop a process that is amenable to large-scale recovery of Sch B from FS. The process starts with solid–liquid extraction of FS by petroleum ether to yield a Sch B-containing extract, which is then purified by removing the relatively nonpolar substances, mostly fatty oils, by an adsorption–desorption step. This is followed by a chromatographic process to isolate the Sch B-enriched fraction that is then used to yield Sch B by crystallization. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie071317b