Chemical composition and cytotoxic activity of essential oil from myrcia laruotteana fruits / Maria Elida A. Stefanello in The journal of essential oil research, Vol. 23 N° 5 (Septembre/Octobre 2011)  

Chemical composition and cytotoxic activity of essential oil from myrcia laruotteana fruits [texte imprimé] / Maria Elida A. Stefanello, Auteur ; Dilamara Riva, Auteur ; Edésio L. Simionatto, Auteur . - 2012 . - pp. 7-10.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 23 N° 5 (Septembre/Octobre 2011) . - pp. 7-10

Mots-clés :	Myrcia laruotteana Myrtaceae Essential oil composition α  -bisabolol oxide B Antiproliferative activity
Index. décimale :	646
Résumé :	The essential oil isolated by hydrodistillation from unripe fruits of Myrcia laruotteana Camb. (Myrtaceae) was analyzed by GC and CG/MS. Forty-four components were identified, representing around 83% of total oil. The major components were α-bisabolol (23.6%) and α-bisabolol oxide B (11.5%). The cytotoxicity of the oil and of a fraction rich in α-bisabolol was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), 786.0 (kidney), NCI-H460 (lung), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The oil exhibited antiproliferative activity against all cell lines (TGI 125 μg/mL). The highest activity of the oil was observed against U251 (TGI 20.46 μg/mL), 786.0 (TGI 20.74 μg/mL), UACC-62 (TGI 26.98 μg/mL) and PC-3 (TGI 27.63 μg/mL) cell lines. The fraction rich in α-bisabol showed a similar activity profile. It was most active against OVCAR-3 (TGI 8.58 μg/mL) and 786.0 (TGI 8.74 μg/mL).
DEWEY :	665
ISSN :	1041-2905
En ligne :	http://www.tandfonline.com/doi/abs/10.1080/10412905.2011.9700473