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Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin in Industrial & engineering chemistry research, Vol. 50 N° 23 (Décembre 2011)
Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin [texte imprimé] / Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2012 . - pp. 13280–13287.
Chimie industrielle
Langues : Anglais (eng)
in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287
Mots-clés : Polymer Hydrogel Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856
