The biological activity and essential oil composition of 17 agathosma (Rutaceae) species / Alvaro M. Viljoen in The journal of essential oil research, Vol. 18 N° Spécial (Juillet 2006)  

The biological activity and essential oil composition of 17 agathosma (Rutaceae) species [texte imprimé] / Alvaro M. Viljoen, Auteur ; Aneesa Moolla, Auteur ; Sandy F. Van Vuuren, Auteur . - 2013 . - pp. 2-16.
Génie Chimique
Langues : Anglais (eng)
in The journal of essential oil research > Vol. 18 N° Spécial (Juillet 2006) . - pp. 2-16

Mots-clés :	Agathosma arida bathii hetulina capensis Agathosnw collina crenulata hirsuta lanata namaquensis ovalifolia ovata parva pubigera pungens roodebergensis stipitata zwarthergense Rutaceae Buchu Essential oil composition Sabinene Linalool β  -pinene Menthone Isomenthone Pulegone Myrcene Limonene p-phellandrene Neral Geranial α  -pinene 1,8-cineole Citronellal Methyl citronellate Antimicrobial activity Anti-inflammatory Toxicity
Résumé :	The essential oil composition, antimicrobial, anti-inflammatory and cytotoxic activities of 17 indigenous Agathosnw species (18 samples) were investigated in order to validate their use in traditional healing. The results were related to the chemical composition of the essential oils as determined by GC and GC/MS. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens: Staphylococcus aureus (ATCC 12600), Bacillus cereus (ATCC 11778), Klebsiella pneumoniae (NCTC 9633) and Candida albicans (ATCC 10231). The anti-inflammatory activity was evaluated using the 5-lipoxygenase assay while the cytotoxic activity was determined using the MTT (3-[4,5-dimethyl-2-thiazol-yl]-2,5-diphenyl-2H-tetrazolium bromide) cellular viability assay. The antimicrobial assay revealed that the most active oil against C. albicans was A. collina (MIC value of 3 mg/mL) whilst the most active oils against B. cereus were A. crenulata and A. pungens (MIC values of 3 mg/mL). Nine of the species had MIC values of 4 mg/mL against the Gram-positive pathogen S. aureus. The oils showed less activity against the Gram-negative pathogen K pneumoniae. All the oils exhibited good in vitro anti-inflammatory activity with A. collina being the most potent (IC50 value of 25.98 ± 1.83 μg/mL). The results show that the oils were strong inhibitors of the enzyme 5-lipoxygenase. The oils proved to be toxic in the MTT assay displaying IC50 values of
ISSN :	1041-2905
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