Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate / Ganapati D. Yadav in Industrial & engineering chemistry research, Vol. 47 N°10 (Mai 2008)  

Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate [texte imprimé] / Ganapati D. Yadav, Auteur . - 2008 . - p. 3358–3363.
Bibliogr. p. 3363
Langues : Anglais (eng)
in Industrial & engineering chemistry research > Vol. 47 N°10 (Mai 2008) . - p. 3358–3363

Mots-clés :	n-Butyl levulinate -- esterification  Immobilized lipases
Résumé :	n-Butyl levulinate is used as an important intermediate having diverse applications. The present work focuses on the synthesis of n-butyl levulinate by esterification of levulinic acid with n-butanol by using immobilized lipases. Novozym 435 (Candida antarctica lipase) was found to be the most efficient catalyst, and tetra-butyl methyl ether was the best solvent. Effects of various parameters were studied to analyze the kinetics and mechanism of the lipase action. Ping-pong bi−bi mechanism with n-butanol substrate inhibition was found to describe the kinetics of the reaction. The kinetic parameters evaluated from initial rate data were used to simulate the experimental results. There was a very good agreement between theory and experiment.
En ligne :	http://pubs.acs.org/doi/abs/10.1021/ie800193f